Drug interactions
Hydrocortisone + Phenindione
Severity: Moderate
Hydrocortisone and Phenindione: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter anticoagulant response unpredictably, and may also raise bleeding risk through gastric mucosal and vascular effects. The INR may rise or fall.
What this interaction means in plain words
Hydrocortisone and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; possible effects on coagulation factors, vascular integrity, and gastric mucosa.
What to do
Check the INR more often when starting, changing, or stopping hydrocortisone, and adjust phenindione to the result.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Phenindione?
MediHelp rates the interaction as moderate. Hydrocortisone and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter anticoagulant response unpredictably, and may also raise bleeding risk through gastric mucosal and vascular effects. The INR may rise or fall.
How serious is the interaction between Hydrocortisone and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the INR more often when starting, changing, or stopping hydrocortisone, and adjust phenindione to the result.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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