Drug interactions
Hydrocortisone + Pneumococcal vaccine heptavalent
Severity: Minor
Hydrocortisone and Pneumococcal vaccine heptavalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pneumococcal conjugate vaccine is non-live and safe to give to patients on corticosteroids. Immune response may be somewhat reduced at higher steroid doses.
What this interaction means in plain words
Hydrocortisone and Pneumococcal vaccine heptavalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroid immunosuppression may reduce antibody response to vaccine antigens.
What to do
Give the vaccine as recommended and do not delay it because of steroid use. Where feasible, vaccinate before starting prolonged immunosuppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Pneumococcal vaccine heptavalent?
MediHelp rates the interaction as minor. Hydrocortisone and Pneumococcal vaccine heptavalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pneumococcal conjugate vaccine is non-live and safe to give to patients on corticosteroids. Immune response may be somewhat reduced at higher steroid doses.
How serious is the interaction between Hydrocortisone and Pneumococcal vaccine heptavalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine as recommended and do not delay it because of steroid use. Where feasible, vaccinate before starting prolonged immunosuppression.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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