Drug interactions
Hydrocortisone + Poliovirus vaccine inactivated
Severity: Moderate
Hydrocortisone and Poliovirus vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids at immunosuppressive doses can blunt the antibody response to inactivated vaccines. Protection after vaccination may therefore be incomplete. Physiological replacement doses of hydrocortisone are much less likely to matter.
What this interaction means in plain words
Hydrocortisone and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-mediated suppression of lymphocyte function and antibody production reduces vaccine immunogenicity.
What to do
Where possible, give the vaccine before starting prolonged high-dose corticosteroid therapy, or defer it until the steroid dose has been reduced. Consider revaccination or checking serological response if it was given during significant immunosuppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Poliovirus vaccine inactivated?
MediHelp rates the interaction as moderate. Hydrocortisone and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids at immunosuppressive doses can blunt the antibody response to inactivated vaccines. Protection after vaccination may therefore be incomplete. Physiological replacement doses of hydrocortisone are much less likely to matter.
How serious is the interaction between Hydrocortisone and Poliovirus vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine before starting prolonged high-dose corticosteroid therapy, or defer it until the steroid dose has been reduced. Consider revaccination or checking serological response if it was given during significant immunosuppression.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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