Drug interactions
Hydrocortisone + Rimonabant
Severity: Minor
Hydrocortisone and Rimonabant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimonabant is a CYP3A4 substrate, and hydrocortisone may only weakly induce this enzyme. Any reduction in rimonabant exposure is expected to be small. The drug has been withdrawn in many markets.
What this interaction means in plain words
Hydrocortisone and Rimonabant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone, increasing rimonabant metabolism.
What to do
No dose adjustment is generally needed. Monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Rimonabant?
MediHelp rates the interaction as minor. Hydrocortisone and Rimonabant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rimonabant is a CYP3A4 substrate, and hydrocortisone may only weakly induce this enzyme. Any reduction in rimonabant exposure is expected to be small. The drug has been withdrawn in many markets.
How serious is the interaction between Hydrocortisone and Rimonabant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor clinical response.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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