Drug interactions
Hydrocortisone + Sertindole
Severity: Moderate
Hydrocortisone and Sertindole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is not a meaningful CYP3A4 inducer at usual doses, so a clinically relevant reduction in sertindole levels is not established. Corticosteroids can lower potassium, which is relevant for QT-prolonging sertindole.
What this interaction means in plain words
Hydrocortisone and Sertindole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-induced hypokalemia may add to the QT-prolonging risk of sertindole; any enzyme effect is minor.
What to do
Monitor serum potassium and magnesium and correct deficits. Perform ECG monitoring if systemic hydrocortisone is given at high doses or for prolonged periods.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Sertindole?
MediHelp rates the interaction as moderate. Hydrocortisone and Sertindole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone is not a meaningful CYP3A4 inducer at usual doses, so a clinically relevant reduction in sertindole levels is not established. Corticosteroids can lower potassium, which is relevant for QT-prolonging sertindole.
How serious is the interaction between Hydrocortisone and Sertindole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits. Perform ECG monitoring if systemic hydrocortisone is given at high doses or for prolonged periods.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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