Drug interactions
Hydrocortisone + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Hydrocortisone and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and corticosteroids promote potassium loss. Together they raise the risk of hypokalemia and dehydration, which can provoke arrhythmias.
What this interaction means in plain words
Hydrocortisone and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium and fluid loss from laxative-induced diarrhea and corticosteroid mineralocorticoid effect.
What to do
Ensure adequate hydration and check electrolytes, especially potassium, in patients on long-term or high-dose steroids or with cardiac risk factors. Correct any deficits before and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrocortisone and Sodium picosulfate / magnesium oxide / anhydrous citric acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Hydrocortisone and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and corticosteroids promote potassium loss. Together they raise the risk of hypokalemia and dehydration, which can provoke arrhythmias.
How serious is the interaction between Hydrocortisone and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check electrolytes, especially potassium, in patients on long-term or high-dose steroids or with cardiac risk factors. Correct any deficits before and after the procedure.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
