Drug interactions
Hydrocortisone + Sulfasalazine
Severity: Minor
Hydrocortisone and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of corticosteroids with sulfasalazine is common in inflammatory bowel disease. There is no strong evidence of a distinct interaction beyond general corticosteroid GI effects, and sulfasalazine itself is not a major ulcerogenic NSAID.
What this interaction means in plain words
Hydrocortisone and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No well-established mechanism; possible minor additive gastrointestinal irritation.
What to do
No specific adjustment is needed. Monitor for GI symptoms and for the usual sulfasalazine hematologic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrocortisone and Sulfasalazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Sulfasalazine?
MediHelp rates the interaction as minor. Hydrocortisone and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Concurrent use of corticosteroids with sulfasalazine is common in inflammatory bowel disease. There is no strong evidence of a distinct interaction beyond general corticosteroid GI effects, and sulfasalazine itself is not a major ulcerogenic NSAID.
How serious is the interaction between Hydrocortisone and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is needed. Monitor for GI symptoms and for the usual sulfasalazine hematologic adverse effects.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
