Drug interactions
Hydrocortisone + Telithromycin
Severity: Moderate
Hydrocortisone and Telithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telithromycin is a strong CYP3A4 inhibitor and can raise corticosteroid levels, whereas the reverse effect of hydrocortisone on telithromycin is negligible. The clinically relevant concern is increased steroid exposure.
What this interaction means in plain words
Hydrocortisone and Telithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Telithromycin inhibits CYP3A4, which may reduce hydrocortisone clearance.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and adrenal suppression during prolonged co-use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Telithromycin?
MediHelp rates the interaction as moderate. Hydrocortisone and Telithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telithromycin is a strong CYP3A4 inhibitor and can raise corticosteroid levels, whereas the reverse effect of hydrocortisone on telithromycin is negligible. The clinically relevant concern is increased steroid exposure.
How serious is the interaction between Hydrocortisone and Telithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia, fluid retention and adrenal suppression during prolonged co-use.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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