Drug interactions
Hydrocortisone + Tetanus toxoid adsorbed or fluid
Severity: Minor
Hydrocortisone and Tetanus toxoid adsorbed or fluid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetanus toxoid is non-live and safe with corticosteroids. High-dose therapy may reduce the antibody response somewhat.
What this interaction means in plain words
Hydrocortisone and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroid immunosuppression may reduce antibody production after vaccination.
What to do
Vaccinate as indicated without delay, including for wound management. Use tetanus immune globulin as normally indicated for high-risk wounds.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as minor. Hydrocortisone and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetanus toxoid is non-live and safe with corticosteroids. High-dose therapy may reduce the antibody response somewhat.
How serious is the interaction between Hydrocortisone and Tetanus toxoid adsorbed or fluid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated without delay, including for wound management. Use tetanus immune globulin as normally indicated for high-risk wounds.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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