Drug interactions
Hydrocortisone + Triamcinolone acetonide injectable
Severity: Minor
Hydrocortisone and Triamcinolone acetonide injectable: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are systemic corticosteroids with additive glucocorticoid effects, and the CYP3A4 induction described is of limited importance. Combining them mostly increases overall steroid exposure and risks of adrenal suppression, hyperglycemia and infection.
What this interaction means in plain words
Hydrocortisone and Triamcinolone acetonide injectable have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive glucocorticoid pharmacodynamic effects; hydrocortisone is a possible weak CYP3A4 inducer.
What to do
Account for the total corticosteroid dose and monitor glucose and signs of steroid excess. Avoid unnecessary duplication of therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Triamcinolone acetonide injectable?
MediHelp rates the interaction as minor. Hydrocortisone and Triamcinolone acetonide injectable have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are systemic corticosteroids with additive glucocorticoid effects, and the CYP3A4 induction described is of limited importance. Combining them mostly increases overall steroid exposure and risks of adrenal suppression, hyperglycemia and infection.
How serious is the interaction between Hydrocortisone and Triamcinolone acetonide injectable?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Account for the total corticosteroid dose and monitor glucose and signs of steroid excess. Avoid unnecessary duplication of therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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