Drug interactions
Hydrocortisone + Triazolam
Severity: Minor
Hydrocortisone and Triazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is at most a weak CYP3A4 inducer, so any reduction in triazolam exposure is likely small. Reduced sedative effect is possible but not well documented.
What this interaction means in plain words
Hydrocortisone and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone increasing triazolam metabolism.
What to do
No dose adjustment is needed. Monitor hypnotic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Triazolam?
MediHelp rates the interaction as minor. Hydrocortisone and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is at most a weak CYP3A4 inducer, so any reduction in triazolam exposure is likely small. Reduced sedative effect is possible but not well documented.
How serious is the interaction between Hydrocortisone and Triazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor hypnotic response.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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