Drug interactions
Hydrocortisone + Troglitazone
Severity: Moderate
Hydrocortisone and Troglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone raises blood glucose and can offset the insulin-sensitizing effect of thiazolidinediones. Troglitazone has been withdrawn from the market.
What this interaction means in plain words
Hydrocortisone and Troglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-induced insulin resistance opposes thiazolidinedione action.
What to do
Monitor blood glucose and adjust antidiabetic therapy during steroid treatment; troglitazone should not be used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Troglitazone?
MediHelp rates the interaction as moderate. Hydrocortisone and Troglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone raises blood glucose and can offset the insulin-sensitizing effect of thiazolidinediones. Troglitazone has been withdrawn from the market.
How serious is the interaction between Hydrocortisone and Troglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust antidiabetic therapy during steroid treatment; troglitazone should not be used.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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