Drug interactions
Hydrocortisone + Troleandomycin
Severity: Moderate
Hydrocortisone and Troleandomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Troleandomycin is a strong CYP3A4 inhibitor that reduces the clearance of corticosteroids, so exposure to hydrocortisone may increase. This can intensify steroid adverse effects.
What this interaction means in plain words
Hydrocortisone and Troleandomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Troleandomycin inhibits CYP3A4, reducing corticosteroid metabolism.
What to do
Monitor for corticosteroid excess such as hyperglycemia, fluid retention and Cushingoid features, and reduce the steroid dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Troleandomycin?
MediHelp rates the interaction as moderate. Hydrocortisone and Troleandomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Troleandomycin is a strong CYP3A4 inhibitor that reduces the clearance of corticosteroids, so exposure to hydrocortisone may increase. This can intensify steroid adverse effects.
How serious is the interaction between Hydrocortisone and Troleandomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as hyperglycemia, fluid retention and Cushingoid features, and reduce the steroid dose if needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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