Drug interactions
Hydrocortisone + Typhoid polysaccharide vaccine
Severity: Minor
Hydrocortisone and Typhoid polysaccharide vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable Vi polysaccharide vaccine is non-live and safe with corticosteroids. The antibody response may be lower with immunosuppressive doses.
What this interaction means in plain words
Hydrocortisone and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroid immunosuppression may reduce antibody production after vaccination.
What to do
Vaccinate on schedule, at least 2 weeks before travel when possible. Reinforce food and water hygiene.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as minor. Hydrocortisone and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Injectable Vi polysaccharide vaccine is non-live and safe with corticosteroids. The antibody response may be lower with immunosuppressive doses.
How serious is the interaction between Hydrocortisone and Typhoid polysaccharide vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate on schedule, at least 2 weeks before travel when possible. Reinforce food and water hygiene.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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