Drug interactions
Hydrocortisone + Xipamide
Severity: Moderate
Hydrocortisone and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic that causes potassium loss, and hydrocortisone has mineralocorticoid activity that also promotes potassium excretion. Combined use increases the risk of hypokalemia, which can provoke arrhythmias and muscle weakness.
What this interaction means in plain words
Hydrocortisone and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal potassium wasting from diuretic action and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium and magnesium periodically and supplement or add a potassium-sparing agent if levels fall. Take extra care in patients on digoxin or with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Xipamide?
MediHelp rates the interaction as moderate. Hydrocortisone and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic that causes potassium loss, and hydrocortisone has mineralocorticoid activity that also promotes potassium excretion. Combined use increases the risk of hypokalemia, which can provoke arrhythmias and muscle weakness.
How serious is the interaction between Hydrocortisone and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and supplement or add a potassium-sparing agent if levels fall. Take extra care in patients on digoxin or with cardiac disease.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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