Drug interactions
Hydrocortisone + Zolpidem
Severity: Minor
Hydrocortisone and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone may weakly induce CYP3A4, which could modestly reduce zolpidem exposure. Any loss of hypnotic effect would likely be small.
What this interaction means in plain words
Hydrocortisone and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Zolpidem belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone increasing zolpidem metabolism.
What to do
No routine adjustment is needed; reassess hypnotic response if sleep control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Zolpidem
Frequently asked questions
Can I take Hydrocortisone with Zolpidem?
MediHelp rates the interaction as minor. Hydrocortisone and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone may weakly induce CYP3A4, which could modestly reduce zolpidem exposure. Any loss of hypnotic effect would likely be small.
How serious is the interaction between Hydrocortisone and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess hypnotic response if sleep control worsens.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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