Drug interactions
Hydroxyprogesterone caproate + Isoniazid
Severity: Minor
Hydroxyprogesterone caproate and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is metabolized partly by CYP3A4, but isoniazid is only a weak inhibitor. A clinically meaningful change in exposure is not expected.
What this interaction means in plain words
Hydroxyprogesterone caproate and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical weak CYP3A4 inhibition by isoniazid.
What to do
No dose adjustment is needed. Routine clinical monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Isoniazid?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyprogesterone caproate is metabolized partly by CYP3A4, but isoniazid is only a weak inhibitor. A clinically meaningful change in exposure is not expected.
How serious is the interaction between Hydroxyprogesterone caproate and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Routine clinical monitoring is sufficient.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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