Drug interactions
Hydroxyprogesterone caproate + Metformin
Severity: Minor
Hydroxyprogesterone caproate and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly impair glucose tolerance and may reduce the effect of antidiabetic drugs. The effect of hydroxyprogesterone caproate on glycemia is generally small.
What this interaction means in plain words
Hydroxyprogesterone caproate and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progestogenic activity can increase insulin resistance, partially opposing metformin.
What to do
Monitor blood glucose when starting or stopping hydroxyprogesterone caproate in a patient with diabetes. Adjust metformin or other therapy only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Metformin?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly impair glucose tolerance and may reduce the effect of antidiabetic drugs. The effect of hydroxyprogesterone caproate on glycemia is generally small.
How serious is the interaction between Hydroxyprogesterone caproate and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping hydroxyprogesterone caproate in a patient with diabetes. Adjust metformin or other therapy only if control worsens.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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