Drug interactions
Ibuprofen / famotidine + Pimozide
Severity: Moderate
Ibuprofen / famotidine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine has been associated with QT prolongation, mainly in renal impairment, and may add to the effect of pimozide. Ibuprofen has no meaningful interaction with pimozide, so the clinical significance is small in most patients.
What this interaction means in plain words
Ibuprofen / famotidine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QTc prolongation from famotidine.
What to do
Monitor ECG in patients with renal impairment or electrolyte disturbances. Consider another acid suppressant if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Ibuprofen / famotidine with Pimozide?
MediHelp rates the interaction as moderate. Ibuprofen / famotidine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine has been associated with QT prolongation, mainly in renal impairment, and may add to the effect of pimozide. Ibuprofen has no meaningful interaction with pimozide, so the clinical significance is small in most patients.
How serious is the interaction between Ibuprofen / famotidine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with renal impairment or electrolyte disturbances. Consider another acid suppressant if the QTc is prolonged.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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