Drug interactions
Idarubicin + Olaparib
Severity: Moderate
Idarubicin and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress bone marrow function, so together they can deepen and prolong cytopenias. This raises the risk of infection, anemia and bleeding.
What this interaction means in plain words
Idarubicin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idarubicin belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from DNA-damaging therapy and PARP inhibition.
What to do
Monitor complete blood counts regularly. Delay or reduce doses if significant cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Idarubicin with Olaparib?
MediHelp rates the interaction as moderate. Idarubicin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow function, so together they can deepen and prolong cytopenias. This raises the risk of infection, anemia and bleeding.
How serious is the interaction between Idarubicin and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly. Delay or reduce doses if significant cytopenias develop.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
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