Drug interactions
Ifosfamide + Rotavirus oral vaccine live
Severity: Contraindicated
Ifosfamide and Rotavirus oral vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotavirus vaccine contains live attenuated virus, which could replicate excessively in a patient immunosuppressed by ifosfamide. This raises the risk of prolonged vaccine-virus gastrointestinal infection, and the vaccine response may be reduced.
What this interaction means in plain words
Ifosfamide and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Chemotherapy-induced immunosuppression allows unchecked replication of live attenuated virus and impairs the vaccine response.
What to do
Avoid live vaccines during ifosfamide therapy and for at least 3 months after it ends. Seek specialist advice if an infant is exposed through a treated household member.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Ifosfamide with Rotavirus oral vaccine live?
MediHelp rates the interaction as contraindicated. Ifosfamide and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rotavirus vaccine contains live attenuated virus, which could replicate excessively in a patient immunosuppressed by ifosfamide. This raises the risk of prolonged vaccine-virus gastrointestinal infection, and the vaccine response may be reduced.
How serious is the interaction between Ifosfamide and Rotavirus oral vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during ifosfamide therapy and for at least 3 months after it ends. Seek specialist advice if an infant is exposed through a treated household member.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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