Drug interactions
Albuterol + Imipramine
Severity: Moderate
Albuterol and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists, which may produce tachycardia, palpitations, arrhythmias and blood pressure changes. The effect is greatest with systemic dosing and is less with inhaled use.
What this interaction means in plain words
Albuterol and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics block norepinephrine reuptake and enhance adrenergic and vascular response to beta-agonists.
What to do
Monitor heart rate, rhythm and blood pressure, especially with high or systemic albuterol doses. Use the lowest effective beta-agonist dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Albuterol with Imipramine?
MediHelp rates the interaction as moderate. Albuterol and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists, which may produce tachycardia, palpitations, arrhythmias and blood pressure changes. The effect is greatest with systemic dosing and is less with inhaled use.
How serious is the interaction between Albuterol and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, especially with high or systemic albuterol doses. Use the lowest effective beta-agonist dose.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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