Drug reference
imipramine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Tricyclic Antidepressants)
Mechanism of action
Neurotransmitter (especially norepinephrine and serotonin) reuptake inhibitor; inhibits reuptake by neuronal membrane; may also down-regulate beta-adrenergic and serotonin receptors
Common side effects
- Dry mouth
- Constipation
- Sedation
- Blurred vision
- Fatigue
- Lethargy
- Weakness
Known interactions (13)
- dronedarone + imipramine Contraindicated
- imipramine + isocarboxazid Contraindicated
- imipramine + phenelzine Contraindicated
- imipramine + pimozide Contraindicated
- imipramine + safinamide Contraindicated
- imipramine + selegiline Contraindicated
- imipramine + thioridazine Contraindicated
- imipramine + tranylcypromine Contraindicated
- imipramine + procarbazine Major
- imipramine + quinidine Major
- imipramine + sotalol Major
- imipramine + indapamide Moderate
- imipramine + pantoprazole Moderate
Related conditions
Frequently asked questions
What drug class is imipramine?
imipramine belongs to: Central Nervous System.
How does imipramine work?
Neurotransmitter (especially norepinephrine and serotonin) reuptake inhibitor; inhibits reuptake by neuronal membrane; may also down-regulate beta-adrenergic and serotonin receptors
What are the common side effects of imipramine?
Dry mouth, Constipation, Sedation, Blurred vision, Fatigue, Lethargy, Weakness
Which drugs interact with imipramine?
dronedarone, isocarboxazid, phenelzine, pimozide, safinamide, selegiline, thioridazine, tranylcypromine, procarbazine, quinidine, sotalol, indapamide, pantoprazole
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