Drug interactions
Indacaterol inhaled + Propranolol
Severity: Major
Indacaterol inhaled and Propranolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is a non-selective beta blocker that opposes indacaterol's beta-2 mediated bronchodilation and can cause severe bronchospasm in patients with COPD or asthma. Both effects reduce bronchodilator efficacy.
What this interaction means in plain words
Indacaterol inhaled and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Competitive beta-2 receptor antagonism by propranolol blocks the agonist action of indacaterol.
What to do
Avoid propranolol in patients using indacaterol. If a beta blocker is essential, use a cardioselective agent with careful respiratory monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Indacaterol inhaled with Propranolol?
MediHelp rates the interaction as major. Indacaterol inhaled and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propranolol is a non-selective beta blocker that opposes indacaterol's beta-2 mediated bronchodilation and can cause severe bronchospasm in patients with COPD or asthma. Both effects reduce bronchodilator efficacy.
How serious is the interaction between Indacaterol inhaled and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propranolol in patients using indacaterol. If a beta blocker is essential, use a cardioselective agent with careful respiratory monitoring.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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