Drug interactions
Indapamide + Ketorolac intranasal
Severity: Moderate
Indapamide and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically and, like other NSAIDs, can reduce the antihypertensive and diuretic effect of indapamide. The combination also raises the risk of acute kidney injury, particularly with volume depletion.
What this interaction means in plain words
Indapamide and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and causes sodium retention, opposing the diuretic and increasing nephrotoxic risk.
What to do
Limit ketorolac to the shortest duration, keep the patient well hydrated, and monitor blood pressure and renal function. Consider an alternative analgesic in older or dehydrated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Indapamide and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is absorbed systemically and, like other NSAIDs, can reduce the antihypertensive and diuretic effect of indapamide. The combination also raises the risk of acute kidney injury, particularly with volume depletion.
How serious is the interaction between Indapamide and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest duration, keep the patient well hydrated, and monitor blood pressure and renal function. Consider an alternative analgesic in older or dehydrated patients.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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