Drug interactions
Indapamide + Lily of the valley
Severity: Major
Indapamide and Lily of the valley: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides, and diuretic-induced hypokalemia increases sensitivity to glycoside toxicity, raising the risk of serious arrhythmias.
What this interaction means in plain words
Indapamide and Lily of the valley can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Potassium and magnesium depletion from indapamide enhances myocardial sensitivity to cardiac glycosides.
What to do
Avoid the herbal product with indapamide. If exposure occurs, check potassium, magnesium and ECG and correct deficits.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Lily of the valley?
MediHelp rates the interaction as major. Indapamide and Lily of the valley can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lily of the valley contains cardiac glycosides, and diuretic-induced hypokalemia increases sensitivity to glycoside toxicity, raising the risk of serious arrhythmias.
How serious is the interaction between Indapamide and Lily of the valley?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the herbal product with indapamide. If exposure occurs, check potassium, magnesium and ECG and correct deficits.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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