Drug interactions
Indapamide + Lithium
Severity: Major
Indapamide and Lithium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can raise serum lithium concentrations and precipitate lithium toxicity, with tremor, confusion, ataxia and arrhythmias. Diuretic-induced electrolyte disturbance may add further cardiac risk.
What this interaction means in plain words
Indapamide and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indapamide belongs to Cardiovascular; Lithium belongs to Central Nervous System.
Why it happens
Thiazide-like diuretics reduce renal lithium clearance by increasing proximal tubular reabsorption secondary to sodium and volume depletion.
What to do
Avoid the combination where possible. If used, reduce the lithium dose, monitor serum lithium closely after initiation or dose change, and watch electrolytes and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indapamide and Lithium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indapamide
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Indapamide with Lithium?
MediHelp rates the interaction as major. Indapamide and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indapamide can raise serum lithium concentrations and precipitate lithium toxicity, with tremor, confusion, ataxia and arrhythmias. Diuretic-induced electrolyte disturbance may add further cardiac risk.
How serious is the interaction between Indapamide and Lithium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, reduce the lithium dose, monitor serum lithium closely after initiation or dose change, and watch electrolytes and renal function.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
