Drug interactions
Indapamide + Lofepramine
Severity: Moderate
Indapamide and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant that can prolong the QT interval. Indapamide-induced hypokalemia or hypomagnesemia raises the risk of arrhythmia.
What this interaction means in plain words
Indapamide and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation with diuretic-induced electrolyte depletion.
What to do
Monitor potassium, magnesium and ECG, especially in older patients or those with heart disease. Correct electrolyte deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Lofepramine?
MediHelp rates the interaction as moderate. Indapamide and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant that can prolong the QT interval. Indapamide-induced hypokalemia or hypomagnesemia raises the risk of arrhythmia.
How serious is the interaction between Indapamide and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium and ECG, especially in older patients or those with heart disease. Correct electrolyte deficits promptly.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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