Drug interactions
Indapamide + Lumefantrine
Severity: Major
Indapamide and Lumefantrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine can prolong the QT interval, and indapamide may cause hypokalemia and hypomagnesemia. Together they raise the risk of torsades de pointes.
What this interaction means in plain words
Indapamide and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation with diuretic-induced electrolyte depletion.
What to do
Check and correct potassium and magnesium before treatment and obtain an ECG. Consider holding indapamide during the antimalarial course.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Lumefantrine?
MediHelp rates the interaction as major. Indapamide and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lumefantrine can prolong the QT interval, and indapamide may cause hypokalemia and hypomagnesemia. Together they raise the risk of torsades de pointes.
How serious is the interaction between Indapamide and Lumefantrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before treatment and obtain an ECG. Consider holding indapamide during the antimalarial course.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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