Drug interactions
Indapamide + Meclofenamate
Severity: Moderate
Indapamide and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can reduce the diuretic and antihypertensive effects of indapamide and increase the risk of acute kidney injury, especially with dehydration or in older patients.
What this interaction means in plain words
Indapamide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, renal function and electrolytes, and keep the patient hydrated. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Meclofenamate?
MediHelp rates the interaction as moderate. Indapamide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can reduce the diuretic and antihypertensive effects of indapamide and increase the risk of acute kidney injury, especially with dehydration or in older patients.
How serious is the interaction between Indapamide and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and keep the patient hydrated. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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