Drug interactions
Indapamide + Metformin
Severity: Minor
Indapamide and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics can raise blood glucose and may modestly weaken the glucose-lowering effect of metformin. At the low doses of indapamide typically used for hypertension the effect is usually small. Glycaemic control may need review after the diuretic is started.
What this interaction means in plain words
Indapamide and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazide-type diuretics can impair insulin secretion and sensitivity, partly through potassium loss.
What to do
Check blood glucose or HbA1c after starting or changing indapamide and adjust antidiabetic therapy if control worsens. Keep serum potassium in the normal range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Other interactions of Metformin
Frequently asked questions
Can I take Indapamide with Metformin?
MediHelp rates the interaction as minor. Indapamide and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide-type diuretics can raise blood glucose and may modestly weaken the glucose-lowering effect of metformin. At the low doses of indapamide typically used for hypertension the effect is usually small. Glycaemic control may need review after the diuretic is started.
How serious is the interaction between Indapamide and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose or HbA1c after starting or changing indapamide and adjust antidiabetic therapy if control worsens. Keep serum potassium in the normal range.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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