Drug interactions
Indapamide + Methyclothiazide
Severity: Moderate
Indapamide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two thiazide-type diuretics gives additive diuresis and additive loss of potassium and sodium. This raises the risk of hypokalemia, hyponatremia and volume depletion, and low potassium can trigger arrhythmias.
What this interaction means in plain words
Indapamide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both drugs inhibit the distal tubular sodium-chloride cotransporter, producing additive urinary electrolyte loss.
What to do
Avoid duplicate thiazide-type therapy where possible. If both are used, monitor serum potassium, sodium and renal function and correct deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indapamide and Methyclothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Methyclothiazide?
MediHelp rates the interaction as moderate. Indapamide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two thiazide-type diuretics gives additive diuresis and additive loss of potassium and sodium. This raises the risk of hypokalemia, hyponatremia and volume depletion, and low potassium can trigger arrhythmias.
How serious is the interaction between Indapamide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide-type therapy where possible. If both are used, monitor serum potassium, sodium and renal function and correct deficits.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
