Drug interactions
Indapamide + Mycophenolate
Severity: Minor
Indapamide and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics are not well documented to alter mycophenolate exposure meaningfully, and the proposed competition for renal anion secretion is theoretical. The main metabolite is cleared largely by glucuronidation and biliary recycling rather than tubular secretion.
What this interaction means in plain words
Indapamide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical competition for renal tubular anion secretion of the mycophenolic acid glucuronide; not firmly established.
What to do
No routine change is needed. Watch for mycophenolate adverse effects such as cytopenias or gastrointestinal upset if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Mycophenolate?
MediHelp rates the interaction as minor. Indapamide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide-type diuretics are not well documented to alter mycophenolate exposure meaningfully, and the proposed competition for renal anion secretion is theoretical. The main metabolite is cleared largely by glucuronidation and biliary recycling rather than tubular secretion.
How serious is the interaction between Indapamide and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for mycophenolate adverse effects such as cytopenias or gastrointestinal upset if renal function declines.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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