Drug interactions
Indapamide + Nitroglycerin rectal
Severity: Moderate
Indapamide and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure by different routes, so their combination can produce additive hypotension. Volume depletion from the diuretic can increase the risk of dizziness, syncope and falls with nitrate use.
What this interaction means in plain words
Indapamide and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotension from nitrate vasodilation and diuretic-induced volume and vascular effects.
What to do
Monitor blood pressure and orthostatic symptoms, especially when starting or increasing either drug. Advise the patient to rise slowly and adjust doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Indapamide and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure by different routes, so their combination can produce additive hypotension. Volume depletion from the diuretic can increase the risk of dizziness, syncope and falls with nitrate use.
How serious is the interaction between Indapamide and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially when starting or increasing either drug. Advise the patient to rise slowly and adjust doses if symptomatic hypotension develops.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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