Drug interactions
Indapamide + Olanzapine / samidorphan
Severity: Moderate
Indapamide and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may enhance the blood pressure lowering of indapamide. Patients may experience dizziness, syncope or falls, particularly at the start of treatment or after dose increases.
What this interaction means in plain words
Indapamide and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from olanzapine's alpha-1 adrenergic blockade and the diuretic's volume depletion and vasodilation.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce the indapamide dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Indapamide and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension and may enhance the blood pressure lowering of indapamide. Patients may experience dizziness, syncope or falls, particularly at the start of treatment or after dose increases.
How serious is the interaction between Indapamide and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce the indapamide dose if hypotension develops.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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