Drug interactions
Indapamide + Olmesartan
Severity: Minor
Indapamide and Olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide tends to lower potassium while olmesartan tends to raise it, so the net effect varies. The combination is commonly prescribed, but volume depletion and hypotension can occur, particularly at initiation.
What this interaction means in plain words
Indapamide and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Opposing potassium effects (kaliuresis versus aldosterone antagonism) and additive blood pressure lowering.
What to do
Check potassium, creatinine and blood pressure after initiation or dose changes. Reduce the diuretic dose if volume depletion develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Indapamide with Olmesartan?
MediHelp rates the interaction as minor. Indapamide and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide tends to lower potassium while olmesartan tends to raise it, so the net effect varies. The combination is commonly prescribed, but volume depletion and hypotension can occur, particularly at initiation.
How serious is the interaction between Indapamide and Olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium, creatinine and blood pressure after initiation or dose changes. Reduce the diuretic dose if volume depletion develops.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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