Drug interactions
Indapamide + Olodaterol inhaled
Severity: Moderate
Indapamide and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can cause hypokalemia and may prolong the QT interval, and beta-2 agonists also lower potassium and can affect cardiac conduction. Together they raise the risk of arrhythmia, particularly at higher doses or with other risk factors.
What this interaction means in plain words
Indapamide and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from diuretic potassium loss and beta-2 mediated cellular potassium uptake, with a further potential QT-prolonging effect.
What to do
Check serum potassium and magnesium at baseline and periodically, and correct deficits. Use an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indapamide and Olodaterol inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Indapamide and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide can cause hypokalemia and may prolong the QT interval, and beta-2 agonists also lower potassium and can affect cardiac conduction. Together they raise the risk of arrhythmia, particularly at higher doses or with other risk factors.
How serious is the interaction between Indapamide and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically, and correct deficits. Use an ECG in patients with other QT risk factors.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
