Drug interactions
Indapamide + Pirbuterol
Severity: Moderate
Indapamide and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirbuterol moves potassium into cells and indapamide increases urinary potassium loss, so together they can produce clinically relevant hypokalemia. This increases the risk of arrhythmias, particularly with other QT-prolonging drugs or digoxin.
What this interaction means in plain words
Indapamide and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 mediated cellular potassium uptake and diuretic-induced renal potassium loss.
What to do
Monitor serum potassium and magnesium, especially at the start of therapy and with frequent pirbuterol use. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Pirbuterol?
MediHelp rates the interaction as moderate. Indapamide and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirbuterol moves potassium into cells and indapamide increases urinary potassium loss, so together they can produce clinically relevant hypokalemia. This increases the risk of arrhythmias, particularly with other QT-prolonging drugs or digoxin.
How serious is the interaction between Indapamide and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially at the start of therapy and with frequent pirbuterol use. Replace potassium as needed.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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