Drug interactions
Indapamide + Promazine
Severity: Major
Indapamide and Promazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine antipsychotic that can prolong the QT interval. Indapamide may cause electrolyte disturbances that lower the threshold for torsades de pointes.
What this interaction means in plain words
Indapamide and Promazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with indapamide-related hypokalemia and hypomagnesemia increasing arrhythmic risk.
What to do
Avoid the combination if possible; otherwise check and correct potassium and magnesium and monitor the ECG for QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Promazine?
MediHelp rates the interaction as major. Indapamide and Promazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Promazine is a phenothiazine antipsychotic that can prolong the QT interval. Indapamide may cause electrolyte disturbances that lower the threshold for torsades de pointes.
How serious is the interaction between Indapamide and Promazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise check and correct potassium and magnesium and monitor the ECG for QTc prolongation.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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