Drug interactions
Indapamide + Romidepsin
Severity: Moderate
Indapamide and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause QT changes and electrolyte disturbances, and indapamide may add to these through hypokalemia and hypomagnesemia. The combination increases the risk of ventricular arrhythmias.
What this interaction means in plain words
Indapamide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation, with diuretic-induced electrolyte depletion raising arrhythmia susceptibility.
What to do
Check and correct potassium and magnesium before each romidepsin dose and monitor ECG in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Romidepsin?
MediHelp rates the interaction as moderate. Indapamide and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause QT changes and electrolyte disturbances, and indapamide may add to these through hypokalemia and hypomagnesemia. The combination increases the risk of ventricular arrhythmias.
How serious is the interaction between Indapamide and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before each romidepsin dose and monitor ECG in patients with additional QT risk factors.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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