Drug interactions
Indapamide + Sacubitril / valsartan
Severity: Moderate
Indapamide and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril/valsartan reduces aldosterone effect and can raise potassium, which may offset indapamide-related potassium loss. Combined diuretic and angiotensin receptor blockade also increases the risk of hypotension and renal dysfunction, especially with volume depletion.
What this interaction means in plain words
Indapamide and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing potassium effects plus additive hypotensive and renal hemodynamic effects of diuretic and angiotensin receptor blockade.
What to do
Monitor blood pressure, renal function and serum potassium after initiation and dose changes. Reduce the diuretic dose if hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Indapamide and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sacubitril/valsartan reduces aldosterone effect and can raise potassium, which may offset indapamide-related potassium loss. Combined diuretic and angiotensin receptor blockade also increases the risk of hypotension and renal dysfunction, especially with volume depletion.
How serious is the interaction between Indapamide and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and serum potassium after initiation and dose changes. Reduce the diuretic dose if hypotension or volume depletion occurs.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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