Drug interactions
Indapamide + Salsalate
Severity: Moderate
Indapamide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID that may blunt diuretic and antihypertensive effects and add to renal risk in volume-depleted patients. The effect is generally smaller than with potent NSAIDs.
What this interaction means in plain words
Indapamide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition causes sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, fluid status and renal function, and keep the salsalate dose as low as practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Salsalate?
MediHelp rates the interaction as moderate. Indapamide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID that may blunt diuretic and antihypertensive effects and add to renal risk in volume-depleted patients. The effect is generally smaller than with potent NSAIDs.
How serious is the interaction between Indapamide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function, and keep the salsalate dose as low as practical.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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