Drug interactions
Indapamide + Sulfamethoxazole
Severity: Moderate
Indapamide and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole (usually with trimethoprim) has been associated with QT prolongation and hyperkalemia or electrolyte disturbances, and indapamide may cause hyponatremia and hypokalemia. The combination may increase arrhythmia and electrolyte risk.
What this interaction means in plain words
Indapamide and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT effects and overlapping electrolyte disturbances.
What to do
Monitor sodium, potassium and magnesium during co-therapy, and obtain an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Indapamide and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole (usually with trimethoprim) has been associated with QT prolongation and hyperkalemia or electrolyte disturbances, and indapamide may cause hyponatremia and hypokalemia. The combination may increase arrhythmia and electrolyte risk.
How serious is the interaction between Indapamide and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sodium, potassium and magnesium during co-therapy, and obtain an ECG in patients with other QT risk factors.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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