Drug interactions
Indapamide + Telmisartan-amlodipine
Severity: Minor
Indapamide and Telmisartan-amlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an angiotensin receptor blocker with a thiazide-like diuretic gives additive blood pressure lowering, and the opposing effects on potassium usually offset one another. Volume depletion, first-dose hypotension and electrolyte disturbances (low sodium or abnormal potassium) can occur, especially in older patients or those with kidney disease.
What this interaction means in plain words
Indapamide and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects; telmisartan reduces aldosterone-mediated potassium loss while indapamide promotes renal potassium and sodium excretion.
What to do
Check blood pressure, serum potassium, sodium and creatinine after starting or changing doses. Correct volume depletion before starting.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indapamide and Telmisartan-amlodipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Telmisartan-amlodipine?
MediHelp rates the interaction as minor. Indapamide and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining an angiotensin receptor blocker with a thiazide-like diuretic gives additive blood pressure lowering, and the opposing effects on potassium usually offset one another. Volume depletion, first-dose hypotension and electrolyte disturbances (low sodium or abnormal potassium) can occur, especially in older patients or those with kidney disease.
How serious is the interaction between Indapamide and Telmisartan-amlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure, serum potassium, sodium and creatinine after starting or changing doses. Correct volume depletion before starting.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
