Drug interactions
Indapamide + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Indapamide and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can lower serum potassium and prolong the QTc interval, and indapamide independently causes potassium loss. Together hypokalemia and arrhythmia risk may be increased.
What this interaction means in plain words
Indapamide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia and QTc effects from beta-2 agonism and thiazide-like diuresis.
What to do
Monitor serum potassium and magnesium, especially at initiation or in patients with cardiac disease, and replace deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Indapamide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can lower serum potassium and prolong the QTc interval, and indapamide independently causes potassium loss. Together hypokalemia and arrhythmia risk may be increased.
How serious is the interaction between Indapamide and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially at initiation or in patients with cardiac disease, and replace deficits promptly.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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