Drug interactions
Indapamide + Venlafaxine
Severity: Moderate
Indapamide and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine can prolong the QT interval, particularly in overdose, and indapamide may add to this directly and via hypokalemia or hypomagnesemia. This raises the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Indapamide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with diuretic-induced electrolyte loss increasing arrhythmia risk.
What to do
Monitor potassium and magnesium and correct deficits. Obtain an ECG if additional QT-prolonging drugs or cardiac disease are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Indapamide with Venlafaxine?
MediHelp rates the interaction as moderate. Indapamide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine can prolong the QT interval, particularly in overdose, and indapamide may add to this directly and via hypokalemia or hypomagnesemia. This raises the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Indapamide and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium and correct deficits. Obtain an ECG if additional QT-prolonging drugs or cardiac disease are present.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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