Drug interactions
Indapamide + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Indapamide and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can lower serum potassium and prolong QTc, and indapamide independently depletes potassium. The combination may increase the risk of hypokalemia and arrhythmia.
What this interaction means in plain words
Indapamide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia and QTc effects from beta-2 agonism and thiazide-like diuresis.
What to do
Monitor serum potassium and magnesium, particularly at initiation or in patients with cardiac disease, and replace deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Indapamide and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can lower serum potassium and prolong QTc, and indapamide independently depletes potassium. The combination may increase the risk of hypokalemia and arrhythmia.
How serious is the interaction between Indapamide and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly at initiation or in patients with cardiac disease, and replace deficits promptly.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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