Drug interactions
Indapamide + Xipamide
Severity: Moderate
Indapamide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are thiazide-like diuretics acting on the distal tubule, so combining them duplicates therapy and adds to sodium and water loss. The risk of hypokalemia, hyponatremia, volume depletion and hypotension rises without much added antihypertensive benefit.
What this interaction means in plain words
Indapamide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic inhibition of the distal tubule sodium-chloride transport with additive electrolyte losses.
What to do
Avoid using two thiazide-type diuretics together unless deliberately intended; if used, monitor serum sodium, potassium, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Xipamide?
MediHelp rates the interaction as moderate. Indapamide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are thiazide-like diuretics acting on the distal tubule, so combining them duplicates therapy and adds to sodium and water loss. The risk of hypokalemia, hyponatremia, volume depletion and hypotension rises without much added antihypertensive benefit.
How serious is the interaction between Indapamide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together unless deliberately intended; if used, monitor serum sodium, potassium, renal function and blood pressure.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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