Drug interactions
Indinavir + Insulin aspart
Severity: Moderate
Indinavir and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is associated with insulin resistance and hyperglycemia, and has been reported to cause new-onset or worsening diabetes. Insulin requirements may increase.
What this interaction means in plain words
Indinavir and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits GLUT4-mediated glucose uptake and may reduce insulin sensitivity, antagonizing insulin.
What to do
Monitor glucose more often when indinavir is started or stopped. Increase the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Frequently asked questions
Can I take Indinavir with Insulin aspart?
MediHelp rates the interaction as moderate. Indinavir and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is associated with insulin resistance and hyperglycemia, and has been reported to cause new-onset or worsening diabetes. Insulin requirements may increase.
How serious is the interaction between Indinavir and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more often when indinavir is started or stopped. Increase the insulin dose as needed.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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