Drug interactions
Indinavir + Isoniazid
Severity: Minor
Indinavir and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a CYP3A4 substrate, but isoniazid is a weak inhibitor and a significant increase is not expected. Both drugs may be hepatotoxic, so combined use needs liver monitoring.
What this interaction means in plain words
Indinavir and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by isoniazid; additive hepatotoxic potential.
What to do
Monitor liver enzymes and no dose change is needed. Report symptoms of hepatitis promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Indinavir with Isoniazid?
MediHelp rates the interaction as minor. Indinavir and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir is a CYP3A4 substrate, but isoniazid is a weak inhibitor and a significant increase is not expected. Both drugs may be hepatotoxic, so combined use needs liver monitoring.
How serious is the interaction between Indinavir and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and no dose change is needed. Report symptoms of hepatitis promptly.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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